Feed Additive for FISH,Chitosan,Chitin

This product uses the physical degradation and special grinding process, has a molecular weight of controllable and fully retain

KORUI CHITIN (Chitosan) A: Introduction KORUI CHITIN oligomeric chitosan physical degradation of the joint development of Jiaxing Corey Biotechnology Co., Ltd. and the Chinese Academy of Sciences Institute of Physics. This product uses the physical degradation and special grinding process, has a molecular weight of controllable and fully retain the chitosan advantages of the natural characteristics, has been the national invention patent. After years of studies have shown that several tests on laboratory animals, aquatic animals, monogastric animals and ruminants, the company KORUI CHITIN of significant physiological activity of chitosan and reliable effect, greatly reduce the chitosan works the effective dose (25ppm have effect) application costs in the actual production of acceptable input and output is high, low molecular weight, the ultrafine powder Chitosan is more conducive to the absorption of animal. As a new type of feed additives, KORUI CHITIN improve immunity, prevent disease, promote growth, regulating gut microflora balance, promote digestion and absorption effects.B: KORUI CHITIN The main function 1. Stimulate the immune system of the animal body, improve the immune system; 2. Enhance disease resistance in animals, to reduce the incidence of; 3. Promote the breeding of beneficial bacteria in the digestive tract, inhibit the growth of harmful bacteria, improving the balance of microflora; 4. Improve feed utilization, improve animal performance; 5. Improve the quality of animal products.C: KORUI CHITIN range of applications and use      For feed, feed additives production 1 As feed additives recommended dosage is added to a variety of animal feed premixes, concentrates; 2 can be growth-promoting agents, combined with antibiotics; 3 associated with drug use, can be used as the animal diseases auxiliary synergist.  D:  KORUI CHITIN Recommended dosage: Unit g / T Aquatic animals 25 to 50 cows 50 to 100 (according to the feed intake: 5 grams) per head daily piglets 50 to 100 pigs from 30 to 40 sows 30 to 50 meat and poultry 30 to 40 Egg and Poultry 30 to 50 E: KORUI CHITIN mechanism 1, the antibacterial mechanism of action: KORUI CHITIN as a natural polymer material, its natural antibacterial properties has been a wide range of knowledge, but has a different mechanism of Gram-positive bacteria and gram-negative bacteria. a, KORUI CHITIN effective group NH2 + On the bacterial cell membrane lipid, protein complexes reaction denatures proteins, changing the permeability of the cell membrane, or bacterial cell wall (especially thick cell wall of Gram-positive bacteria, compact structure, rich in teichoic acid ) forming a negative charge environment, chitosan damage the integrity of the cell wall, or make the cell wall tends to dissolve until the cells died. b, KORUI CHITIN by permeation through the porous cell walls (particularly Gram-negative bacteria cell wall is thin, and low molecular weight chitosan into the bacterial internal crosslinking loose), destruction of the colloidal state of the inclusions in the cytoplasm, its flocculation , degeneration, bacteria can not be a normal physiological activities, or directly interfering with the genetic material of the negatively charged DNA and RNA and inhibit the reproduction of bacteria, resulting in the death of microorganisms2, Immunomodulatory mechanism: KORUI CHITIN molecule contains a large amount of the amino group having a positively charged, and the surface of the macrophages and T lymphocytes having a negative electrically positive and negative charges attract each other, and can activate the immune cells. When KORUI CHITIN activated macrophages and T lymphocytes, issued a directive to the B cells to produce a variety of immune globulin, thereby enhancing the body's immune response and humoral immune responses. Can KORUI CHITIN maintain alkaline micro-environment of the body to create an activated lymphocytes, enhance the cellular immunity, humoral immunity, and NK cell function, strengthen the role of the immune surveillance environment. The to promote KORUI CHITIN interleukins, interferons, tumor necrosis factor cytokine production N-acetyl-D-glucose the Ammonia (GlcNAc) or D-Glycosaminoglycan (GlcN) KORUI CHITIN group some of the surface of immune cells containing GlcNAc and GlcN residues receptor, activation of immune cells, such as when the combination of these receptors KORUI CHITIN macrophage cell surface receptor, activated macrophages release IL-1 expression caused by T-cell surface IL-2 body, accelerate the mature T cells release IL-2. Further, since having electropositive KORUI CHITIN, mononuclear cells can be absorbed from the blood vessel, aggregation in the organization, and the formation of macrophages; also directly stimulate the local tissue, promote cell proliferation and then evolved into macrophages; Therefore, KORUI CHITIN promote neutrophil and macrophage proliferation, enhanced protective the lgA mucosal immune reaction induced delayed hyper-responsiveness and produce the loop resistance. KORUI CHITIN animal immune function has many regulatory role, both effective to increase nonspecific Free function, the regulation of specific immune function. Mechanism from existing reports, chitosan mechanism of regulation of immune function may be achieved through the regulation of the immune cells of nitric oxide and arachidonic acid generation ways.a, through the regulation of inducible NO synthase (NOS) activity, affect the immune cells in the formation of NO, thereby regulating the immune function. NO is an important messenger molecule that newly discovered, widespread in the animal body tissue has an important role in the physiological activity of many roles, such as macrophages, cytotoxicity, antibacterial effect and tumor killing effect of all its synthesis NO.b, affect immune cells arachidonic acid (AA) generated through the regulation of phospholipase A2 (PLA2) activity, thereby regulating the immune function. Regulating mechanism of the in vivo environment KORUI CHITIN can adsorb H +, also with a considerable number of acidic substances together, therefore, KORUI CHITIN can inhibit gastric acid secretion, and in too much stomach acid, protect the gastric mucosa. KORUI CHITIN of adsorption H + also can buffer the acidic environment of the animals, to improve the animal environment. Promote the absorption of nutrients KORUI CHITIN its molecules carry positive charge connected to the cell membrane, so closely integrated in the membrane cell protein structural changes resulting in the transmembrane channel open, conducive to the absorption of nutrients; another can Microvillidensity height increases, the density increased, the intestinal absorption expand the area that is conducive to the absorption and utilization of nutrients.    3, prevention and treatment of mastitis in dairy cows The major cause of mastitis in dairy cows is a variety of non-specific pathogenic microorganisms, including exposure to infectious agents, including Streptococcus agalactiae, Staphylococcus aureus, and mycoplasma, environmental pathogens, including: Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus, Pseudomonas, of which 80% -90 infections caused by Gram-positive bacteria Staphylococcus aureus and Streptococcus. Followed by the so-called Gram-negative bacteria such as E. coli. The conventional solution is to use antibiotics, as well as other chemical antibacterial drugs, so that cause drug residues, affecting the quality of the milk, but also produce resistant strains, endangering the security of the health of cows and milk consumption, the use of oligomeric chitosan sugar instead of antibiotics and antimicrobial agents, prevention and treatment of mastitis in dairy cows reason: 1 Chitosan has a strong immune activity, and antibacterial function, basically covering the scope of its anti-bacterial, cow mastitis pathogens 2 Oligomeric chitosan is a natural active substances, 3 We are in the processing production, the use of physical degradation, not introduce other preparations, do not cause pollution

Feed Additive for FISH,Chitosan,Chitin